ANGPTL2 cDNA ORF Clone, Human, C-DDK (Flag®) tag

Cat: HG11014-M-F

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ANGPTL2 cDNA ORF Clone, Human, C-DDK (Flag®) tag General Information

Gene

Species
Human
NCBI Ref Seq
RefSeq ORF Size
1482 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human angiopoietin-like 2 with Flag tag.

Plasmid

Promoter
Enhanced CMV promoter
Vector
pCMV2-FLAG
Restriction Sites
HindIII + XhoI (5.4kb + 1.53kb)
Tag Sequence
FLAG Tag Sequence: GATTACAAGGATGACGACGATAAG
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.

Screening

Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression

Storage & Shipping

Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

ANGPTL2 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ANGPTL2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Validated Images

Human EG-VEGF / prokineticin-1 Gene Plasmid Map 7151

ANGPTL2 cDNA ORF Clone, Human, C-DDK (Flag®) tag Alternative Names

ARP2 cDNA ORF Clone, Human;HARP cDNA ORF Clone, Human

ANGPTL2 Background Information

The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism. Morinaga et al. demonstrated that genetic depletion of Angptl2 confers amelioration of the mouse kidney fibrosis induced by a unilateral ureteral obstruction, implicating that ANGPTL2, predominantly in the renal tubular compartments, activates the transforming growth factor-β signaling and vice versa through miR-221. Angiopoietin-like protein 2 (ANGPTL2) maintains tissue homeostasis by inducing inflammation and angiogenesis. It is produced in infiltrating immune cells or resident cells, such as adipocytes, vascular endothelial cells, and tumor cells. The classic sequential cascade of P. gingivalis LPS → inflammatory cytokine induction is well established. However, in the current study, we reveal a novel cascade comprising sequential P. gingivalis LPS → ANGPTL2 → integrin α5β1 → inflammatory cytokine induction, which might be responsible for inducing potent periodontal disorganization activity in gingival epithelial cells. Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemic disease. That MAC-3-positive immune cells, including infiltrating bone marrow-derived macrophages and activated microglia, express abundant angiopoietin-like protein (ANGPTL) 2 in ischemic mouse brain in a transient middle cerebral artery occlusion (MCAO) model. Both neurological deficits and infarct volume decreased in transient MCAO model mice established in Angptl2 knockout (KO) relative to wild-type mice. Acute brain inflammation after ischemia-reperfusion, as estimated by expression levels of pro-inflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor alpha (TNF)-α, was significantly suppressed in Angptl2 KO compared to control mice.
Full Name
angiopoietin-like 2

ANGPTL2 cDNA ORF Clone, Canine, Related Products

Product Name Catalog#(PDF)
ANGPTL2 cDNA ORF Clone in Cloning Vector, Canine DG70033-G
ANGPTL2 cDNA ORF Clone, Canine, untagged DG70033-UT
ANGPTL2 cDNA ORF Clone, Canine, C-GFPSpark® tag DG70033-ACG
ANGPTL2 Lentiviral cDNA ORF Clone, Canine, C-GFPSpark® tag DG70033-ACGLN
ANGPTL2 cDNA ORF Clone, Canine, C-OFPSpark® tag DG70033-ACR
ANGPTL2 cDNA ORF Clone, Canine, C-DDK (Flag®) tag DG70033-CF
ANGPTL2 cDNA ORF Clone, Canine, N-DDK (Flag®) tag DG70033-NF
ANGPTL2 cDNA ORF Clone, Canine, C-His tag DG70033-CH
ANGPTL2 cDNA ORF Clone, Canine, N-His tag DG70033-NH
ANGPTL2 cDNA ORF Clone, Canine, C-HA tag DG70033-CY
ANGPTL2 cDNA ORF Clone, Canine, N-HA tag DG70033-NY
ANGPTL2 cDNA ORF Clone, Canine, C-Myc tag DG70033-CM
ANGPTL2 cDNA ORF Clone, Canine, N-Myc tag DG70033-NM

ANGPTL2 cDNA ORF Clone, Rat, Related Products

Product Name Catalog#(PDF)
ANGPTL2 cDNA ORF Clone in Cloning Vector, Rat RG81033-U
ANGPTL2 cDNA ORF Clone, Rat, untagged RG81033-UT
ANGPTL2 cDNA ORF Clone, Rat, C-GFPSpark® tag RG81033-ACG
ANGPTL2 Lentiviral cDNA ORF Clone, Rat, C-GFPSpark® tag RG81033-ACGLN
ANGPTL2 cDNA ORF Clone, Rat, C-OFPSpark® tag RG81033-ACR
ANGPTL2 cDNA ORF Clone, Rat, C-DDK (Flag®) tag RG81033-CF
ANGPTL2 cDNA ORF Clone, Rat, N-DDK (Flag®) tag RG81033-NF
ANGPTL2 cDNA ORF Clone, Rat, C-His tag RG81033-CH
ANGPTL2 cDNA ORF Clone, Rat, N-His tag RG81033-NH
ANGPTL2 cDNA ORF Clone, Rat, C-HA tag RG81033-CY
ANGPTL2 cDNA ORF Clone, Rat, N-HA tag RG81033-NY
ANGPTL2 cDNA ORF Clone, Rat, C-Myc tag RG81033-CM
ANGPTL2 cDNA ORF Clone, Rat, N-Myc tag RG81033-NM
ANGPTL2 qPCR Primer Pairs, Rat RP300997

ANGPTL2 cDNA ORF Clone, Mouse, Related Products

Product Name Catalog#(PDF)
ANGPTL2 cDNA ORF Clone in Cloning Vector, Mouse MG50301-M
ANGPTL2 cDNA ORF Clone, Mouse, untagged MG50301-UT
ANGPTL2 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50301-ACG
ANGPTL2 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG50301-ACGLN
ANGPTL2 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG50301-ACR
ANGPTL2 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG50301-CF
ANGPTL2 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG50301-NF
ANGPTL2 cDNA ORF Clone, Mouse, C-His tag MG50301-CH
ANGPTL2 cDNA ORF Clone, Mouse, N-His tag MG50301-NH
ANGPTL2 cDNA ORF Clone, Mouse, C-HA tag MG50301-CY
ANGPTL2 cDNA ORF Clone, Mouse, N-HA tag MG50301-NY
ANGPTL2 cDNA ORF Clone, Mouse, C-Myc tag MG50301-CM
ANGPTL2 cDNA ORF Clone, Mouse, N-Myc tag MG50301-NM
ANGPTL2 qPCR Primer Pairs, Mouse MP200324

ANGPTL2 cDNA ORF Clone, Human, Related Products

Product Name Catalog#(PDF)
ANGPTL2 cDNA ORF Clone in Cloning Vector, Human HG11014-M
ANGPTL2 cDNA ORF Clone, Human, untagged HG11014-UT
ANGPTL2 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG11014-ACGLN
ANGPTL2 cDNA ORF Clone, Human, C-GFPSpark® tag HG11014-ACG
ANGPTL2 cDNA ORF Clone, Human, C-OFPSpark® tag HG11014-ACR
ANGPTL2 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG11014-CF
ANGPTL2 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG11014-NF
ANGPTL2 cDNA ORF Clone, Human, C-His tag HG11014-CH
ANGPTL2 cDNA ORF Clone, Human, N-His tag HG11014-NH
ANGPTL2 cDNA ORF Clone, Human, C-HA tag HG11014-CY
ANGPTL2 cDNA ORF Clone, Human, N-HA tag HG11014-NY
ANGPTL2 cDNA ORF Clone, Human, C-Myc tag HG11014-CM
ANGPTL2 cDNA ORF Clone, Human, N-Myc tag HG11014-NM
ANGPTL2 qPCR Primer Pairs, Human HP100975
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