Reacts with: Mouse
Has cross-reactivity in ELISA with
Recombinant Mouse TNF-alpha / TNFa protein (Catalog#50349-MNAE)
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TNF-alpha / TNFa (rM TNF-alpha / TNFa; Catalog#50349-MNAE; NP_038721.1; Leu 80-Leu 235).
Monoclonal Rabbit IgG Clone #009
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-DIF Antibody;Anti-TNF-a Antibody;Anti-TNF-alpha Antibody;Anti-Tnfa Antibody;Anti-TNFalpha Antibody;Anti-Tnfsf1a Antibody;Anti-TNFSF2 Antibody
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD12a; p55/6) and TNF-R2 (TNF receptor type 2; CD12b; p75/8), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.
Hector J, et al. (2007) TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res. 39(4): 250-5. Berthold-Losleben M, et al. (2008) The TNF-alpha System: Functional Aspects in Depression, Narcolepsy and Psychopharmacology. Curr Neuropharmacol. 6(3): 193-202.