Anti-Neuroserpin Antibody (Rabbit Monoclonal antibody) General Information
Reacts with: Human
Recombinant Human SerpinI1 protein (Catalog#11107-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human SerpinI1 (rh SerpinI1; Catalog#11107-H08H; NP_005016.1; Met 1-Leu 410).
Monoclonal Rabbit IgG Clone #001
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Neuroserpin Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Neuroserpin Antibody Alternative Names
Anti-neuroserpin Antibody;Anti-PI12 Antibody
Neuroserpin Background Information
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein which belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. Neuroserpin is predominantly expressed in the brain, and is expressed in the late stages of neurogenesis during the process of synapse formation. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. Neuroserpin may also protect neurons from cell damage by tissue-type plasminogen activator. Defects of neuroserpin are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B).
serpin peptidase inhibitor, clade I (neuroserpin), member 1
Schrimpf SP. et al., 1997, Genomics. 40 (1): 55-62. Hill RM. et al., 2002, Ann N Y Acad Sci. 971: 406-15. Yepes M. et al., 2004, Thromb. Haemost. 91 (3): 457-64. Galliciotti G. et al., 2006, Front Biosci. 11: 33-45.