Anti-Pepsinogen II Antibody

Cat: 12072-RP01

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Anti-Pepsinogen II Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Pepsinogen II Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Pepsinogen II
Immunogen
Recombinant Human Pepsinogen C / PGC protein (Catalog#12072-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human Pepsinogen C / PGC (rh Pepsinogen C / PGC; Catalog#12072-H08H; NP_002621.1; Met 1-Ala 388). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Anti-Pepsinogen II Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Pepsinogen II Antibody Alternative Names

Anti-PEPC Antibody;Anti-PGII Antibody

Pepsinogen II Background Information

Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

Full Name
progastricsin (pepsinogen C)
References
  • Richter C, et al. (1998) Mechanism of activation of the gastric aspartic proteinases: pepsinogen, progastricsin and prochymosin. Biochem J. 1 (335): 481-90.
  • Westerveld BD, et al. (1987) Gastric proteases in Barrett's esophagus. Gastroenterology. 93 (4): 774-8.
  • Ichinose M, et al. (1991) Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer. Jpn J Cancer Res. 82 (6): 686-92.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Pepsinogen II Antibody Rabbit Monoclonal ELISA 80097-R008
    Anti-Pepsinogen II Antibody Rabbit Polyclonal ELISA 80097-RP01
    Anti-Pepsinogen II Antibody Rabbit Polyclonal ELISA 80097-T16
    Anti-Pepsinogen II Antibody Mouse Monoclonal ELISA,IHC-P 12072-MM07
    Anti-Pepsinogen II Antibody Rabbit Polyclonal ELISA 12072-T16
    Anti-Pepsinogen II Antibody Rabbit Polyclonal ELISA 12072-RP02
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