Anti-Pentraxin 3 Antibody (Rabbit Monoclonal antibody) General Information
Anti-Pentraxin 3 Antibody
Reacts with: Human
Human Pentraxin 3
Recombinant Human PTX3 / Pentraxin 3 / TSG-14 protein (Catalog#12082-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human PTX3 / Pentraxin 3 / TSG-14 (rh PTX3 / Pentraxin 3 / TSG-14; Catalog#12082-H08H; NP_002843.2; Met 1-Ser 381).
Monoclonal Rabbit IgG Clone #070
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Pentraxin 3 Antibody (Rabbit Monoclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Pentraxin 3 Antibody Alternative Names
Anti-PTX3 Antibody;Anti-TNFAIP5 Antibody;Anti-TSG-14 Antibody
Pentraxin 3 Background Information
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4. Mantovani A., et al., 2003, Vaccine. 21:S43-S47. Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72. Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30. Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.