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LFA-3 / CD58  Protein

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Expressionswirt: Human Cells  
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12409-H02H-50
12409-H02H-100
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Expressionswirt: Human Cells  
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12409-H08H-50
12409-H08H-100
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Expressionswirt: Human Cells  
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90190-C08H-50
90190-C08H-100
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100 µg 
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LFA-3 / CD58 Ähnliche Signalwege

    LFA-3 / CD58 Zusammenfassung und Proteininformation

    LFA-3 / CD58 Hintergrund

    Zusammenfassung der Gene: This gene encodes a member of the immunoglobulin superfamily. LFA-3 is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. LFA-3 is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]
    General information above from NCBI
    Untereinheitenstruktur: Interacts with CD2.
    Subzelluläre Position: Isoform 1: Cell membrane; Single-pass type I membrane protein.
    Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor.
    Sequenzähnlichkeit: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.C
    General information above from UniProt

    CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

    LFA-3 / CD58 Alternative Namen

    LFA3, [Cynomolgus]
    ag3,CD58,CD58 antigen,CD58 molecule,LFA3,LFA-3,lymphocyte function-associated antigen 3,RP5-1086K13.2,surface glycoprotein LFA-3, [human]

    LFA-3 / CD58 Ähnliche Studien

  • Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16.
  • Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5.
  • Horejsí V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.
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