Anti-Lipocalin-2 Antibody

Cat: 80058-RP01

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Anti-Lipocalin-2 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-Lipocalin-2 Antibody
Applications
ELISA
Species reactivity
Reacts with: Rat
Specificity
Rat Lipocalin-2
Immunogen
Recombinant Rat LCN2 / NGAL protein (Catalog#80058-R08B)
Preparation
Produced in rabbits immunized with purified, recombinant Rat LCN2 / NGAL (rR LCN2 / NGAL; Catalog#80058-R08B; P30152; Met 1-Asn 198). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-Lipocalin-2 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Lipocalin-2 Background Information

Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, oesophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival and morphogenesis.
Full Name
lipocalin 2
References
  • Schmidt-Ott KM, et al. (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens. 15(4): 442-9.
  • Bolignano D, et al. (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288(1): 10-6.
  • Soni SS, et al. (2010) NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 42(1): 141-50.
  • Bolignano D, et al. (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest. 40(3): 273-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Lipocalin-2 Antibody Mouse Monoclonal ELISA 80058-MM04
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal ELISA,IHC-P 80058-RP02
    Anti-Lipocalin-2 Antibody Rabbit Monoclonal ELISA 80058-R023
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal ELISA,IHC-P 50060-RP02
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal ELISA 50060-RP01
    Anti-Lipocalin-2 Antibody Rabbit Monoclonal ELISA 50060-R211
    Anti-Lipocalin-2 Antibody Mouse Monoclonal ELISA,IHC-P 10222-MM04
    Anti-Lipocalin-2 Antibody Rabbit Monoclonal ELISA 10222-R210
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal ELISA,IHC-P 10222-RP02
    Anti-Lipocalin-2 Antibody Rabbit Monoclonal WB,ELISA 10222-R128
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal WB,ELISA 10222-T48
    Anti-Lipocalin-2 Antibody Rabbit Polyclonal WB,ELISA 10222-RP01
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