Anti-LAMP2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse LAMP2 / CD107b protein (Catalog#50791-M08H)
Produced in rabbits immunized with purified, recombinant Mouse LAMP2 / CD107b (rM LAMP2 / CD107b; Catalog#50791-M08H; P17047-1; Leu 26-Asn 379). LAMP2 / CD107b specific IgG was purified by Mouse LAMP2 / CD107b affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-LAMP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-LAMP2 Antibody Alternative Names
Anti-CD107b Antibody;Anti-Lamp-2 Antibody;Anti-Lamp-2a Antibody;Anti-Lamp-2b Antibody;Anti-Lamp-2c Antibody;Anti-LampII Antibody;Anti-LGP-B Antibody;Anti-Mac3 Antibody
LAMP2 Background Information
LAMP2 (Lysosomal-associated membrane protein 2), also known as CD17b (Cluster of Differentiation 17b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. In human, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.
lysosomal-associated membrane protein 2
Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.