Anti-IL36 alpha / IL-1F6 Antibody

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Anti-IL36 alpha / IL-1F6 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-IL36 alpha / IL-1F6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human IL36 alpha / IL-1F6
Immunogen
Recombinant Human IL1F6 / IL36A protein (Catalog#10607-HNAE)
Preparation
Produced in rabbits immunized with purified, recombinant Human IL1F6 / IL36A (rh IL1F6 / IL36A; Catalog#10607-HNAE; Q9UHA7; Met 1-Phe 158). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-IL36 alpha / IL-1F6 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-IL36 alpha / IL-1F6 Antibody: Alternative Names

Anti-1E Antibody; Anti-FIL Antibody; Anti-FIL1 Antibody; Anti-FIL1(EPSILON) Antibody; Anti-FIL1E Antibody; Anti-IL-1F6 Antibody; Anti-IL1(EPSILON) Antibody; Anti-IL1E Antibody; Anti-IL1F6 Antibody; Anti-IL36A Antibody

IL36 alpha / IL-1F6 Background Information

Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.
Full Name
interleukin 36, alpha
References
  • Tripodi D, et al. (2012) IL-36 a new member of the IL-1 family cytokines. J Biol Regul Homeost Agents. 26(1):7-14.
  • Towne JE, et al. (2004) Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J Biol Chem. 279(14): 13677-88.
  • Kumar S, et al. (2000) Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275(14): 10308-14.
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