Anti-IL10RB Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-IL10RB Antibody
Species reactivity
Reacts with: Mouse
Immunogen
Recombinant Mouse IL10RB / IL10R2 protein (Catalog#50846-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse IL10RB / IL10R2 (rM IL10RB / IL10R2; Catalog#50846-M08H; NP_032375.2; Met 1-Ser 222). IL10RB / IL10R2 specific IgG was purified by Mouse IL10RB / IL10R2 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Anti-IL10RB Antibody (Rabbit Polyclonal antibody) Validated Applications
| Application |
Dilution |
Notes |
| WB |
1:500-1:1000 |
|
| ELISA |
1:25000-1:50000 |
|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-IL10RB Antibody (Rabbit Polyclonal antibody) Images
Anti-IL10RB rabbit polyclonal antibody at 1:500 dilution
Lane A: Jurkat Whole Cell Lysate
Lysates/proteins at 30 μg per lane.
Secondary
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.
Developed using the Odyssey technique.
Performed under reducing conditions.
Predicted band size:37 kDa
Observed band size:37 kDa
Anti-IL10RB Antibody Alternative Names
Anti-6620401D04Rik Antibody;Anti-AI528744 Antibody;Anti-CRF2-4 Antibody;Anti-Crfb4 Antibody;Anti-D16H21S58 Antibody;Anti-D21S58h Antibody;Anti-IL-10R2 Antibody;Anti-Il10r2 Antibody
IL10RB Background Information
Interleukin 1 receptor, beta subunit (IL1RB/IL-1RB) also known as Cytokine receptor family 2 member 4, Interleukin-1 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-1 receptor. IL1RB/IL-1RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 1 receptor complex. Coexpression of this and IL1RA proteins has been shown to be required for IL1-induced signal transduction. Defects in IL1RB/IL-1RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Full Name
interleukin 10 receptor, beta
References
Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.
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