ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-His tag

Cat: HG13997-NH

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ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-His tag General Information

Gene

Species
Human
NCBI Ref Seq
RefSeq ORF Size
321 bp
Description
Full length Clone DNA of Human ATPase inhibitory factor 1 with N terminal His tag.

Plasmid

Promoter
Enhanced CMV promoter
Vector
Tag Sequence
His Tag Sequence: CACCATCACCACCATCATCACCACCATCAC
Sequencing Primers
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
Quality Control
The plasmid is confirmed by full-length sequencing.

Screening

Antibiotic in E.coli
Kanamycin
Antibiotic in Mammalian cell
Hygromycin
Application
Stable or Transient mammalian expression

Storage & Shipping

Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ATPase Inhibitory Factor 1 Background Information

Heme oxygenase-1 (HO-1) and ATPase inhibitory factor (ATPIF) 1 is often overexpressed in different types of cancer cells. To gain a physiological significance, we treated the synthetic flavonoids in colon cancer cells, HT29 and HCT116 cells and confirmed that overexpression of both HO-1 and ATPIF1 was critical for tumor cell death with an impaired mitochondrial energetics. It would provide a strategy for developing selective anti-tumor candidates. A transgene-based model of a heteroplasmic lethal mtDNA deletion (mtDNAΔ) in adult Drosophila muscle. Stimulation of autophagy, activation of the PINK1/parkin pathway or decreased levels of mitofusin result in a selective decrease in mtDNAΔ. Decreased levels of mitofusin and increased levels of ATPIF1, an inhibitor of ATP synthase reversal-dependent mitochondrial repolarization, result in a further decrease in mtDNAΔ levels. The loss of ATPIF1 strongly protects against antimycin-induced ETC dysfunction and cell death by allowing for the maintenance of mitochondrial membrane potential. Inhibition of ATPIF1 ameliorates complex III blockade in primary hepatocytes, a cell type afflicted in severe mitochondrial disease, that inhibition of ATPIF1 can ameliorate severe ETC dysfunction in mitochondrial pathology.
Full Name
ATPase inhibitory factor 1

ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, Related Products

Product Name Catalog#(PDF)
ATPase Inhibitory Factor 1 cDNA ORF Clone in Cloning Vector, Mouse MG51315-U
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, untagged MG51315-UT
ATPase Inhibitory Factor 1 Lentiviral cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51315-ACGLN
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-GFPSpark® tag MG51315-ACG
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-GFPSpark® tag MG51315-ANG
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-OFPSpark® tag MG51315-ACR
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-OFPSpark® tag MG51315-ANR
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-DDK (Flag®) tag MG51315-CF
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-DDK (Flag®) tag MG51315-NF
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-His tag MG51315-CH
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-His tag MG51315-NH
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-HA tag MG51315-CY
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-HA tag MG51315-NY
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, C-Myc tag MG51315-CM
ATPase Inhibitory Factor 1 cDNA ORF Clone, Mouse, N-Myc tag MG51315-NM
ATPase Inhibitory Factor 1 qPCR Primer Pairs, Mouse MP201192

ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, Related Products

Product Name Catalog#(PDF)
ATPase Inhibitory Factor 1 cDNA ORF Clone in Cloning Vector, Human HG13997-G
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, untagged HG13997-UT
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-GFPSpark® tag HG13997-ACG
ATPase Inhibitory Factor 1 Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG13997-ACGLN
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-GFPSpark® tag HG13997-ANG
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-OFPSpark® tag HG13997-ACR
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-OFPSpark® tag HG13997-ANR
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-DDK (Flag®) tag HG13997-CF
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-DDK (Flag®) tag HG13997-NF
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-His tag HG13997-CH
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-HA tag HG13997-CY
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-HA tag HG13997-NY
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, C-Myc tag HG13997-CM
ATPase Inhibitory Factor 1 cDNA ORF Clone, Human, N-Myc tag HG13997-NM
ATPase Inhibitory Factor 1 qPCR Primer Pairs, Human HP102653
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