Anti-GBA3 Antibody (PE)

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Anti-GBA3 Antibody (PE) (Rabbit Monoclonal antibody) General Information

Product name
Anti-GBA3 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human GBA3
Immunogen
Recombinant Human GBA3 protein (Catalog#11593-H08B)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human GBA3 (rh GBA3; Catalog#11593-H08B; NP_066024.1; Met 1-Leu 469) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Rabbit IgG Clone #008
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
5 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-GBA3 Antibody (PE) (Rabbit Monoclonal antibody) Images

Human GBA3 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Rabbit anti-GBA3. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.

Anti-GBA3 Antibody (PE): Alternative Names

Anti-CBG Antibody; Anti-CBGL1 Antibody; Anti-GBA3 Antibody; Anti-GLUC Antibody; Anti-KLrP Antibody; Anti-MGC104276 Antibody; Anti-MGC126878 Antibody

GBA3 Background Information

Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
Full Name
glucosidase, beta, acid 3 (gene/pseudogene)
References
  • Yahata K., et al.,(2000), Molecular cloning and expression of a novel klotho-related protein. J. Mol. Med. 78:389-394.
  • de Graaf M., et al., (2001), Cloning and characterization of human liver cytosolic beta-glycosidase.Biochem. J. 356:907-910.
  • Berrin J.-G., et al.,(2002), Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.Eur. J. Biochem. 269:249-258.

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