|Vector Type||Mammalian Expression Vector|
|Expression Method||Constiutive, Stable / Transient|
|Selection In Mammalian Cells||Hygromycin|
Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.
The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.
|Ferret IFNG ORF mammalian expression plasmid, C-GFPSpark tag||FG60007-ACG|
|Ferret IFNG ORF mammalian expression plasmid, C-OFPSpark / RFP tag||FG60007-ACR|
|Ferret IFNG ORF mammalian expression plasmid, C-Flag tag||FG60007-CF|
|Ferret IFNG ORF mammalian expression plasmid, C-His tag||FG60007-CH|
|Ferret IFNG ORF mammalian expression plasmid, C-Myc tag||FG60007-CM|
|Ferret IFNG ORF mammalian expression plasmid, C-HA tag||FG60007-CY|
|Ferret IFNG Gene cDNA clone plasmid||FG60007-G|
|Ferret IFNG ORF mammalian expression plasmid, His tag||FG60007-G-H|
|Ferret IFNG ORF mammalian expression plasmid, N-Flag tag||FG60007-NF|
|Ferret IFNG ORF mammalian expression plasmid, N-His tag||FG60007-NH|
|Ferret IFNG ORF mammalian expression plasmid, N-Myc tag||FG60007-NM|
|Ferret IFNG ORF mammalian expression plasmid, N-HA tag||FG60007-NY|
|Ferret IFNG natural ORF mammalian expression plasmid||FG60007-UT|
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IFN gamma, also known as IFNG, is a secreted protein which belongs to the type I I interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages, and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.