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E-Cadherin / CDH1 / E-cad / CD324 Antikörper, Monoklonale Antikörper von Hasen

  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
  • Human E-Cadherin/CDH1/E-cad/CD324 Immunofluorescence(IF) 16029
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Mensch CDH1 Produktinformation zu Antikörpern
Immunogen:Recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad protein (Catalog#10204-H08H)
Clone ID:032
Ig-Typ:Rabbit IgG
Konzentration:
Endotoxin:
Rezeptur:0.2 μm filtered solution in PBS
Vorbereitung:This antibody was obtained from a rabbit immunized with purified, recombinant Human E-cadherin / CDH1 / Cadherin-1 / E-Cad (rh E-cadherin / CDH1 / Cadherin-1 / E-Cad; Catalog#10204-H08H; NP_004351.1; Met1-Ile707).
Mensch CDH1 Antibody IHC Application Image
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
[Klicken Sie, um das Bild zu vergrößern]
Caption:
Immunochemical staining of human E-cadherin in human gastric cancer with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit MAb, Immunohistochemistry
[Klicken Sie, um das Bild zu vergrößern]
Caption:
Immunochemical staining of human E-cadherin in human skin with rabbit monoclonal Antibody (5 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of epithelial cells.
Other CDH1 Antibody Products
Reaktivität: Human  
Anwendungen: ELISA  WB  IHC-P  IF  ICC/IF  
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    10204-MM08-F-25
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    Anwendungen: ELISA  
      10204-R055-50
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      50 µg 
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        10204-MM07-50
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        10204-MM07-100
        50 µg 
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        Anwendungen: FCM  IF  ICC/IF  
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        10204-MM08-P-25
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        25 Test 
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        Anwendungen: FCM  
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        10204-MM08-50
        10204-MM08-200
        10204-MM08-100
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        Anwendungen: ELISA  WB  IHC-P  IHC-Fr  
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        10204-RP02-50
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        Reaktivität: Human  
        Anwendungen: WB  IP  
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        10204-R056-50
        10204-R056-100
        50 µg 
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        Reaktivität: Human  
        Anwendungen: ELISA  
          10204-RP01-400
          10204-RP01-200
          10204-RP01-100
          400 µg 
          200 µg 
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          Reaktivität: Human  
          Anwendungen: ELISA  
            10204-MM12-50
            10204-MM12-200
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            50 µg 
            200 µg 
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            10204-MM04-50
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            50 µg 
            200 µg 
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            Reaktivität: Human  
            Anwendungen: FCM  
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            10204-MM08-A-25
            10204-MM08-A-100
            25 Test 
            100 Tests 
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            Reaktivität: Mouse  
            Anwendungen: ELISA  WB  IHC-P  IP  
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            50671-RP02-50
            50671-RP02-200
            50671-RP02-100
            50 µg 
            200 µg 
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            Reaktivität: Mouse  
            Anwendungen: ELISA  IHC-P  
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            50671-RP01-400
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            50671-RP01-100
            400 µg 
            200 µg 
            100 µg 
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            Reaktivität: Mouse  
            Anwendungen: ELISA  WB  IHC-P  IP  
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            50671-T60-50
            50671-T60-200
            50671-T60-100
            50 µg 
            200 µg 
            100 µg 
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            Reaktivität: Rat  
            Anwendungen: 
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            80274-T50-50
            80274-T50-200
            80274-T50-100
            50 µg 
            200 µg 
            100 µg 
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            Reaktivität: Rat  
            Anwendungen: ELISA  
              80274-RP01-400
              80274-RP01-200
              80274-RP01-100
              400 µg 
              200 µg 
              100 µg 
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              Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

              Lane A: NIH3T3 Whole Cell Lysate

              Lane B: Hela Whole Cell Lysate

              Lysates/proteins at 30 μg per lane.

              Secondary

              Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

              Developed using the ECL technique.

              Performed under reducing conditions.

              Predicted band size:15 kDa

              Observed band size:17 kDa

              E-Cadherin/CDH1/E-cad/CD324 Hintergrund

              Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

              Mensch E-Cadherin/CDH1/E-cad/CD324 Referenzen
            • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
            • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
            • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.
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