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CSF1R / MCSF Receptor / CD115 Antikörper, Pab von Hasen, Antigen Affinity Purified

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Human CSF1R Produktinformation zu Antikörpern
Immunogen:Recombinant Human CSF1R / M-CSFR / CD115 protein (Catalog#10161-H20B2)
Clone ID:
Ig-Typ:Rabbit IgG
Konzentration:
Endotoxin:
Rezeptur:0.2 μm filtered solution in PBS with 5% trehalose
Vorbereitung:Produced in rabbits immunized with purified, recombinant Human CSF1R / M-CSFR / CD115 (rh CSF1R / M-CSFR / CD115; Catalog#10161-H20B2; NP_005202.2; Lys543-Asp922). CSF1R / M-CSFR / CD115 specific IgG was purified by Human CSF1R / M-CSFR / CD115 affinity chromatography.
Human CSF1R Leitfaden zur Nutzung von Antikörpern
Spezifität:Human CSF1R / M-CSFR / CD115
Anwendung:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CSF1R / M-CSFR / CD115. The detection limit for Human CSF1R / M-CSFR / CD115 is approximately 0.00245 ng/well.

IHC-P: 0.1-2 μg/mL

Lagerung:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CSF1R Antibody IHC Application Image
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CSF1R in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CSF1R in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other CSF1R Antibody Products
MCSF Receptor/CSF1R/CD115 Hintergrund

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.

Human MCSF Receptor/CSF1R/CD115 Referenzen
  • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
  • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
  • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
  • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
  • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
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    • CSF1R / MCSF Receptor / CD115 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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