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CD2  Protein

All CD2 Reagents

Expressionswirt: Human Cells  
  • Slide 1
10982-H08H-10
10982-H08H-20
10 µg 
20 µg 
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Expressionswirt: Human Cells  
  • Slide 1
50537-M08H-20
50537-M08H-50
20 µg 
50 µg 
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Expressionswirt: Human Cells  
  • Slide 1
80158-R02H-20
80158-R02H-100
20 µg 
100 µg 
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Expressionswirt: Human Cells  
  • Slide 1
90300-C02H-20
90300-C02H-100
20 µg 
100 µg 
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Expressionswirt: Human Cells  
  • Slide 1
90300-C08H-20
90300-C08H-100
20 µg 
100 µg 
Add to Cart
Expressionswirt: Human Cells  
  • Slide 1
70107-D02H-100
70107-D02H-20
100 µg 
20 µg 
Add to Cart
Expressionswirt: Human Cells  
  • Slide 1
70107-D08H-20
70107-D08H-100
20 µg 
100 µg 
Add to Cart

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CD2 Ähnliche Signalwege

CD2 Zusammenfassung und Proteininformation

CD2 Hintergrund

Zusammenfassung der Gene: CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it
General information above from NCBI
Untereinheitenstruktur: Interacts with CD2AP (By similarity). Interacts with PSTPIP1.
Subzelluläre Position: Membrane; Single-pass type I membrane protein.
Sequenzähnlichkeit: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
General information above from UniProt

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). CD2 has been shown to set quantitative thresholds in T cell activation both in vivo and in vitro. Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

CD2 Alternative Namen

T11,SRBC,LFA-2, [homo-sapiens]
RP4-655N15.2,SRBC,T11,CD2,FLJ46032, [human]
Cd2,LFA-2,Ly37,Ly-37, [mouse]
Ly37,LFA-2,Ly-37, [mus-musculus]

CD2 Ähnliche Studien

  • Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
  • Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
  • McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.
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