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CD155 / PVR Antikörper, Monoklonale Antikörper von Hasen

  • CD155 / PVR Antibody, Rabbit MAb
  • CD155 / PVR Antibody, Rabbit MAb, Immunofluorescence
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Maus PVR Produktinformation zu Antikörpern
Immunogen:Recombinant Mouse CD155 / PVR protein (Catalog#50259-M08H)
Clone ID:305
Ig-Typ:Rabbit IgG
Konzentration:
Endotoxin:
Rezeptur:0.2 μm filtered solution in PBS
Vorbereitung:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD155 / PVR (rM CD155 / PVR; Catalog#50259-M08H; NP_081790.1; Met1-Arg345).
Maus PVR Antibody IF Application Image
CD155 / PVR Antibody, Rabbit MAb, Immunofluorescence
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Caption:
Immunofluorescence staining of Mouse PVR(m CD155) in raw264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Mouse PVR (m CD155) monoclonal antibody (10 µg/ml) at 4℃ overnight. Then cells were stained with the Alexa Fluor® 488-conjugated (left panel, captured by laser confocal scanning microscope; right panel, captured by fluorescence microscope) Goat Anti-rabbit IgG secondary antibody, countstained with DAPI (blue). Positive staining was localized to plasma membrane.
Maus PVR Antibody FC Application Image
CD155 / PVR Antibody, Rabbit MAb
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Caption:
Flow cytometric analysis of Mouse PVR(CD155) expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse PVR(CD155), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other PVR Antibody Products
CD155/PVR Hintergrund

CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Maus CD155/PVR Referenzen
  • Freistadt MS, et al. (2000) Hematopoietic cells from CD155-transgenic mice express CD155 and support poliovirus replication ex vivo. Microb Pathog. 29(4): 203-12.
  • Sato T, et al. (2004) Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells. 9(9): 791-9.
  • Kakunaga S, et al. (2004) Enhancement of serum- and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/poliovirus receptor/CD155 through the Ras-Raf-MEK-ERK signaling. J Biol Chem. 279(35): 36419-25.
  • Sato T, et al. (2005) Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin, and of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci. 96(9): 578-89.
  • Minami Y, et al. (2007) Involvement of up-regulated Necl-5/Tage4/PVR/CD155 in the loss of contact inhibition in transformed NIH3T3 cells. Biochem Biophys Res Commun. 352(4): 856-60.
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    Katalog: 50259-R305-50
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    Datasheet & Documentation

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