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AK2 / Adenylate kinase 2 Antibody, Rabbit MAb

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Human AK2 Produktinformation zu Antikörpern
Immunogen:Recombinant Human AK2 protein (Catalog#13146-H20B)
Clone ID:025
Ig-Typ:Rabbit IgG
Konzentration:
Endotoxin:
Rezeptur:0.2 μm filtered solution in PBS with 5% trehalose
Vorbereitung:This antibody was obtained from a rabbit immunized with purified, recombinant Human AK2 (rh AK2; Catalog#13146-H20B; P54819-1; Met1-Ile239).
Human AK2 Leitfaden zur Nutzung von Antikörpern
Spezifität:Human AK2
Anwendung:WB, ELISA, IHC-P

WB: 1-10 μg/ml

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human AK2. The detection limit for Human AK2 is approximately 0.00975 ng/well.

IHC-P: 1-10 μg/mL

Lagerung:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human AK2 Antibody WB Application Image
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb
Human AK2 Antibody IHC Application Image
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Caption:
Immunochemical staining of human AK2 in human kidney with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
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Caption:
Immunochemical staining of human AK2 in human liver with rabbit monoclonal antibody (5 µg/mL, formalin-fixed paraffin embedded sections).
AK2 / Adenylate kinase 2 Antibody, Rabbit MAb, Immunohistochemistry
Other AK2 Antibody Products
AK2 / Adenylate kinase 2 Hintergrund

Adenylate kinase 2 (AK2) belongs to the Adenylate kinase family that contains three isozymes: AK1, AK2 and AK3. Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Adenylate kinase2 (AK2) is expressed in mitochondrial intermembrane space. It may play a role in apoptosis. It has been demonstrated that in apoptotic cells AK2 was translocated into the cytosol concomitantly with cytochronme C. Mutations in this gene are the cause of reticular dysgenesis. These mutations result in absent or strongly decreased protein expression. It has been also established that AK2 is specifically expressed in the stria vascularis region of the inner ear, which provides an explanation of the sensorineural deafness in these individuals. 

Human AK2 / Adenylate kinase 2 Referenzen
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106-11.
  • Bruns GA, et al. (1977) Adenylate kinase 2, a mitochondrial enzyme. Biochem Genet. 15 (5-6): 477-86.
  • Khler C, et al. (1999) Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis. FEBS Lett. 447 (1): 10-2.
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